Abstract
The normocytic normochromic anemia is one of signs of progressing chronic kidney diseases mainly related to absolute or relative decreasing of production of erythropoietin and iron deficiency. The last decade discovery of hepcidin (regulator of iron homeostasis) and also various factors and signaling pathways regulating its metabolism the pathophysiology of anemia under chronic kidney diseases is understood significantly better. As a result, dramatically increased research concerning development of potentially new pharmaceuticals that can be used for treatment of kidney anemia with more or less efficiency and safety. The review words actual conceptions of physiological and pathological role of iron and also about main mechanisms of regulation its metabolism in human organism. The particular attention is given to hepcidin playing a key role in regulation of extra-cellular content of iron. Furthermore, the issues are covered related to risk profile of actual approaches to therapy of anemia under chronic kidney diseases and also certain potentially dangerous methods of treatment that can become available in nearest perspective.
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