Abstract
The negative NK cell maturation checkpoint Foxo1.
Highlights
Previous findings showed that the transcription factor Foxo1 plays critical roles in regulating the development of common lymphoid progenitors as well as T and B cells in a highly cell- and context-specific manner
It can be speculated that other components, in addition to the above factors and Foxo1, in the mTOR signaling pathway and/or in the PI3K signaling pathway in general might be involved in Natural killer (NK) cell development and/or maturation
The most recent studies reveal that epigenetic modification of the genome and silencing of PLZF are involved in NK cell memory after cytomegalovirus infection in humans [4]
Summary
Previous findings showed that the transcription factor Foxo1 plays critical roles in regulating the development of common lymphoid progenitors as well as T and B cells in a highly cell- and context-specific manner. Both the regulatory subunit (p85) and the catalytic subunit (p110) of the class I PI3Ks have been shown to positively regulate NK cell terminal maturation [2]. MTOR, PDK1 (a kinase upstream of mTOR), and E4BP4 (a basic leucine zipper transcription factor downstream of mTOR) have recently been demonstrated to be positively control NK cell development and maturation [2].
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