The negative affectivity dimension of Type D personality associated with increased risk for acute ischemic stroke and white matter hyperintensity

Abstract

ObjectiveThis study was conducted to examine the relationship among type D personality, acute ischemic stroke (AIS), and white matter hyperintensity (WMH). MethodsIn a cross-sectional study conducted between September 2020 and June 2021, 235 patients aged 50–85 years with first-ever ischemic cerebrovascular disease, including 146 males and 89 females, were enrolled. All participants underwent the Type D Scale-14 test containing negative affectivity (NA) and social inhibition (SI) subscales. Clinical and laboratory data were also collected for analysis. The patients were divided into the AIS group (n = 148) and the transient ischemic attack (TIA) group (n = 87) according to whether there was an acute lesion. ResultsPatients with type D personality had a higher frequency of AIS and LAA and a higher level of WMH. Multiple logistic regression showed that the NA score was related to a 1.11-fold increase in the odds of AIS (95% CI: 1.03–1.19). Neither NA nor SI showed a clear association with a higher frequency of LAA. Higher scores of NA (OR = 1.07, 95% CI: 1.01–1.15), SI (OR = 1.11, 95% CI: 1.03–1.19), and the interaction between the two dimensions (OR = 1.03, 95% CI: 1.01–1.05) were independently associated with an increased load of WMH. ConclusionType D personality was related to AIS and WMH. In particular, it was NA, not SI, affected the occurrence of AIS. Our findings may provide new insights regarding behavioral vulnerability for the development of cerebrovascular disorders.