The need of experimental inhalation studies in animals for the problem of the influence of cigarette smoke on the induction of lung cancer

Abstract

This report stresses the great need for experimental model systems which permit duplication of the human habit of cigarette smoking as closely as possible in laboratory animals. The discussion intends to stimulate concentrated efforts of and collaboration between scientists from various disciplines of chemistry, biology, pathology and experimental cancer research in developing and pursuing large scaleinhalation work with fresh cigarette smoke. It is hoped that acute and chronic inhalation studies in animals with fresh cigarette smoke and their combination with exposure to other factors, such as air pollutants, viruses, radiation, will be of great value for clarification of causes and pathogenesis of lung cancer in man.