Abstract
The fact that male urine and testis tissue contain estrogenic activity has been known for some time. Fee, Marrian, Parkes (1), Glimm and Wadehn (2), Lacqueur and de Jongh (3), Zondek (4, 5), and Loewe (6) have reported the presence of estrogenic substance in male urines. Dodds, Greenwood, and Gallimore (7), Laqueur and de Jongh (3), and Brouha and Simmonet (8) have reported estrogenic activity in testis. Most of the workers have confined themselves to a qualitative study by means of the reaction on spayed mice or rats. Fee, Marrian, and Parkes have suggested that the active material is identical with the female sex hormone “estrin” on the basis of the marked uterine hypertrophy observed in spayed female rats and the positive vaginal smear reaction. Zondek§ makes the assertion that the estrogenic substance in stallion urine is similar to the follicular hormone on the basis of the production of uterine hypertrophy, an antimasculine action, the induction of lactation in the male guinea pig, and the positive ...
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