Abstract
Evolution of the initial “three-point attachment model” resulted in the understanding that an interaction in at least three configuration-dependent points is needed for a chiral selector to recognize entantiomers. Thermodynamic enantioselectivity of this interaction can result in chiral discrimination of the enantiomers, with the exception of a temperature range where enthalpic and entropic contributions to the free energy of discrimination balance each other. Similarly, a three-point interaction is needed for a chiral inductor to modify enantiospecifically a prochiral molecule. The difference between a theoretical interaction point and real interaction sites in chemical molecules is emphasized. The role of conformational rigidity of chiral species is discussed in relation to the dependence of spatial arrangement of three active points on the configuration of the species. Chirality 9:99–102, 1997. © 1997 Wiley-Liss, Inc.
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