Abstract
OBJECTIVES: interleukin-1 has been implicated in the mechanisms responsible for preterm parturition inthe setting of intrauterine infection. This cytokine is produced by human decidua, stimulates prostaglandin production by intrauterine tissues, and induces preterm parturition in mice. The purpose of this study was to determine whether pretreatment with the natural interlukin-1 receptor antagonist can block interleukin-1-induced preterm parturition in mice. STUDY DESIGN: Balb/CJ female mice impregnated by B6D2 F-1 male mice were randomly allocated toone of the following treatment groups: (1) saline solution ( n = 15), (2) human recombinant interleukin-1 α or human recombinant interleukin-1 β ( n = 12), (3) human recombinant interleukin-1 receptor antagonist ( n = 13), and (4) human recombinant interleukin-1 receptor antagonist plus human recombinant interleukin-1 ( n = 24). RESULTS: An interleukin-1 dose of 10 g per mouse induced preterm parturition in all cases.Pretreatment with interleukin-1 receptor antagonist (dose 1 mg per animal) prevented interleukin-1-induced preterm parturition. interleukin-1 receptor antagonist administration was not associated with demonstrable side effects including behavioral changes, vaginal bleeding, duration of pregnancy, and pregnancy outcome. CONCLUSION: Our results suggest that interleukin-1-induced preterm delivery in mice is mediated by theinterleukin-1 receptor. ( Am J Obstet Gynecol 1992;167:1041–5.)
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