Abstract
Garudan kizhangu ennai is a polyherbal Siddha formulation widely used for various skin diseases, especially alopecia areata, mentioned in the Siddha literature "Siddha vaidya thirattu". Alopecia areata can be correlated with the term "Puzhuvettu" in the Siddha system of medicine. This is a complex autoimmune condition that causes non-scarring hair loss. Nowadays, the prevalence rate of alopecia is higher among children and adolescents. Hence, this review aims to emphasise the potential role of Garudan kizhangu ennai in managing alopecia areata in Siddha. The ingredients of Garudan kizhangu ennai are briefly explained here in Siddha aspects, actions, chemical constituents and pharmacological aspects. All the above information was collected from various scientific articles and books. The scientific studies explored the ingredients of Garudan kizhangu ennai, predominantly possessing antihistamine, antivenom, antioxidant, antipyretic, anti-inflammatory, analgesic, antimicrobial, antidiabetic, immunomodulatory, and anticancer activities. This review revealed that the Garudan kizhangu ennai could be effective for managing alopecia areata, and further clinical studies will be needed to prove the drug's efficacy.
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