Abstract
Patch clamp techniques were used to record voltage-sensitive calcium and potassium currents from NG108-15 cells. N-(6-aminohexyl)-5-chloro-1-naphthalene-sulphonamide (W7), a calmodulin (CaM) antagonist and its more potent (10 times) 5-iodo-1-C 8 analogue (J8) inhibited these currents in a dose-dependent manner. The inhibition was not dependent on internal or external Ca 2+. W7 was about four times more potent as an inhibitor of the transient potassium current (IC 50 = 8 μM) than of the M-current or of the calcium current. J8 was also selective for the potassium currents (IC 50 values: transient current 4 μM, M-current 11 μM) compared to the calcium current (IC 50 36 μM). It is suggested that the inhibition does not result from an anti-CaM action of the compounds.
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