Abstract
Objectives: Experimentally, inhibition of the Na+/H+-exchanger [NHE] has been shown to be cardioprotective. However, a clinical benefit could not be demonstrated unequivocally, most likely because of difficulties to deliver the correct dose of NHE-inhibitor at the right time. Whether the infusion of cardioplegic solutions has the potential to affect the myocardial concentration of NHE-inhibitors has not been evaluated so far.
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