Abstract
The myxobacterial strain Stigmatella aurantiaca MYX-030 was selected as promising source for the discovery of new biologically active natural products by our screening methodology. The isolation, structure elucidation and initial biological evaluation of the myxocoumarins derived from this strain are described in this work. These compounds comprise an unusual structural framework and exhibit remarkable antifungal properties.
Highlights
Despite declining interest of most big R&D-driven chemical companies in recent years, natural products continue to serve as one of the most important sources of new bioactive chemical entities, both in the pharmaceutical [1,2,3,4] as well as in the agrochemical industry [5,6,7,8]
The myxobacterial strain Stigmatella aurantiaca MYX-030 was selected as promising source for the discovery of new biologically active natural products by our screening methodology
The isolation, structure elucidation and initial biological evaluation of the myxocoumarins derived from this strain are described in this work
Summary
Despite declining interest of most big R&D-driven chemical companies in recent years, natural products continue to serve as one of the most important sources of new bioactive chemical entities, both in the pharmaceutical [1,2,3,4] as well as in the agrochemical industry [5,6,7,8]. The myxobacterial strain Stigmatella aurantiaca MYX-030 was selected as promising source for the discovery of new biologically active natural products by our screening methodology.
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