Abstract
Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.
Highlights
Candida auris was first seen as an agent of human disease in 2009, when it had been isolated from the ear canal of a patient in Japan[1]
We prospected the use of a predatory yeast, Saccharomycopsis schoenii, as a potential biocontrol agent against human fungal pathogens of the Candida clade with a focus on C. auris
Equal numbers of dimorphic S. schoenii and ovoid C. auris NCPF8985#20 cells were seeded on minimal media agar on microscopy slides to offer solid support for a potential S. schoenii interaction
Summary
Received: 25 May 2018 Accepted: 25 September 2018 Published: xx xx xxxx resistant Candida auris. We show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills both sensitive and multidrug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol. Candida auris was first seen as an agent of human disease in 2009, when it had been isolated from the ear canal of a patient in Japan[1] It has subsequently spread rapidly around the world and is a major health threat on a global scale having been associated with potentially lethal infections in patients in ICUs in Eastern and South Asia, South Africa, Europe, the USA, and South America. We show that S. schoenii efficiently attacks and kills a range of pathogenic Candida species, including the newly emerged human pathogenic fungus C. auris. Efficient predation as shown here could be useful for biocontrol purposes in either clinical settings for skin clearance or in agricultural settings for combatting plant pathogens
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
