The Mutant Menage- Mit Family Translocation Renal Cell Carcinoma

Abstract

Microphthalmia associated transcription factor (MiT) family translocation renal cell carcinoma is neoplasm which enunciates genetic fusions within members of MiT family of transcription factors, especially TFE3 gene and TFEB gene. Neoplasm frequently incriminates the adult population ≤ 35 years of age with an intense female predilection. Tumefaction exhibits a papillary, solid or alveolar pattern of tumour configuration and is composed of clear cells or non-cohesive, pseudo stratified, eosinophilic epithelial cells. Tumour cells are pervaded with voluminous cytoplasm and pleomorphic nuclei of advanced grade. Neoplastic cells are intensely immune reactive to TFE3 or TFEB, PAX8, cathepsin K, CD10, alpha methyacyl CoA racemase (AMACR), vimentin or E-cadherin. Tumour cells appear immune non-reactive to cytokeratin, epithelial membrane antigen (EMA), carbonic anhydrase IX(CAIX), CD45, calretinin and smooth muscle actin(SMA). MiT family translocation renal cell carcinoma requires segregation from neoplasms such as clear cell papillary renal cell carcinoma, clear cell renal cell carcinoma, epithelioid angiomyolipoma, chromophobe renal cell carcinoma or papillary renal cell carcinoma. Neoplasm may be appropriately alleviated by cogent manoeuvers as surgical extermination of the neoplasm.