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Abstract
Strains having recA and recC mutations were tested for UV mutability. A recA strain is UV-stsable at doses that are demonstrably mutagenic in its Rec+ derivative. Strains of recC genotype are not UV-stable, but produce UV-induced mutations at frequencies significantly lower than those produced at the same doses in Rec+ strains. The results support the hypothesis that most UV-induced mutations originate as errors in recombinational repair of single-strand gaps in DNA.
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Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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