Abstract
Amultivariate regression statisticstrategy was developed to clarify multi-components content-effect correlation ofpanaxginseng saponins extract and predict the pharmacological effect by components content. In example 1, firstly, we compared pharmacological effects between panax ginseng saponins extract and individual saponin combinations. Secondly, we examined the anti-platelet aggregation effect in seven different saponin combinations of ginsenoside Rb1, Rg1, Rh, Rd, Ra3 and notoginsenoside R1. Finally, the correlation between anti-platelet aggregation and the content of multiple components was analyzed by a partial least squares algorithm. In example 2, firstly, 18 common peaks were identified in ten different batches of panax ginseng saponins extracts from different origins. Then, we investigated the anti-myocardial ischemia reperfusion injury effects of the ten different panax ginseng saponins extracts. Finally, the correlation between the fingerprints and the cardioprotective effects was analyzed by a partial least squares algorithm. Both in example 1 and 2, the relationship between the components content and pharmacological effect was modeled well by the partial least squares regression equations. Importantly, the predicted effect curve was close to the observed data of dot marked on the partial least squares regression model. This study has given evidences that themulti-component content is a promising information for predicting the pharmacological effects of traditional Chinese medicine.
Highlights
Traditional Chinese medicine is becoming more and more popular all over the world because of their safety and efficacy [1,2,3,4]
The multivariate regression statistic strategy could assess the contribution of each component to the efficacy of herbal medicine, and, in turn, predict the potential efficacy of herbal medicine according to its components compositions
The six saponinsofNGR1, GRg1, Ginsenoside Rd (GRd), Ginsenoside Re (GRe), Ginsenoside Rb1 (GRb1), and GRa3 for saponin combination could be recognized as the pharmacological markers of panax ginseng saponins extract both in vitro and in vivo
Summary
Traditional Chinese medicine is becoming more and more popular all over the world because of their safety and efficacy [1,2,3,4]. The relationship between multiple components of traditional Chinese medicine and the efficacy of herbal medicines should be a focus of attention, which strongly restricts dose-effect application, especially in model research. The herbal medicine analysis and the curative effect should be associated with each other, which can guarantee the clinical safety and effectiveness of traditional. The traditional dose-effect models, such as direct model, effect compartment model, and indirect response model, were not appropriate to be applied in traditional Chinese medicine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
