Abstract
It is no exaggeration to say that virtually all the concepts which together constitute the current model of virus replication are derived from work with the T-even bacteriophages. These include virus eclipse, now known to be due to uncoating of viral nucleic acid; more or less complete replacement of the host genome as a source of messenger RNA by the viral genome; and independent synthesis of viral nucleic acid and protein subunits followed by their combination culminating in virus maturation and release. Indeed, the case for working with a phage, T-even or some other, rather than with an animal virus appears overwhelming at first sight. Yet such a view would ignore the value of comparative studies. In fact, work with animal viruses has contributed considerably to our understanding of virus replication. Often this contribution has been merely to emphasize that the T-even phages are structures very highly adapted for infecting...
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