The Multiple Faces of Nodular Trichoblastoma: Review of the Literature with Case Presentation.

Gerardo Cazzato,Anna Colagrande,Antonietta Cimmino,Francesca Arezzo,Leonardo Resta,Sara Sablone,Lucia Lospalluti,Giuseppe Ingravallo,Teresa Lettini

doi:10.3390/dermatopathology8030032

Gerardo Cazzato, Anna Colagrande + Show 7 more

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https://doi.org/10.3390/dermatopathology8030032

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Abstract

Trichoblastoma (TB) is a rare biphasic benign adnexal neoplasm originating from follicular germ cells but clinically, it can simulate basal cell carcinoma (BCC), making the diagnosis more difficult. There are several variants of Trichoblastoma and a good knowledge of these is essential for correct diagnosis and management. We report two new cases observed in the last year at our Pathological Anatomy Operative Unit, and conduct a careful review of the literature, from the first description of this lesion by Headington in 1970 to the most recent classifications.

Highlights

Trichoblastoma (TB) is a rare biphasic benign adnexal neoplasm originating from follicular germ cells but clinically, it can simulate basal cell carcinoma (BCC), making the diagnosis more difficult
We conducted a literature review using Pubmed and Web of Science (WOS) search engines, entering the words “trichoblastoma” OR “cutaneous trichoblastoma” OR “trichoblastic carcinoma” and/or “adnexal neoplasm” OR “cutaneous adnexal neoplasm” to retrieve descriptions referring to this entity
The first case was a 73-year-old woman who complained of the persistence of a skin lesion at the level of the right nasolabial groove (Figure 1), that had been present for several years

Summary

Introduction

Trichoblastoma (TB) is a rare biphasic benign adnexal neoplasm originating from follicular germ cells but clinically, it can simulate basal cell carcinoma (BCC), making the diagnosis more difficult. There are several variants of Trichoblastoma and a good knowledge of these is essential for correct diagnosis and management. Among lesions with a favorable clinical outcome [1,2], rare cases of trichoblastic carcinoma as an evolution of TB have been described [3]. This lesion can simulate basal cell carcinoma (BCC), making the diagnosis more difficult. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations

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