Abstract
The transcription factor NANOG regulates self-renewal and pluripotency in embryonic cells, and itsdownregulation leads to cell differentiation. Recent studies have linked upregulation of NANOG in various cancers and the regulation of expression of different molecules, andvice versa, to induce proliferation, metastasis, invasionand chemoresistance. Thus NANOG is an oncogene that functions by inducing stem cells'circuitriesand heterogeneity in cancers. Understanding NANOG's role in various cancers may lead to it becoming atherapeutic target to halt cancer progression. TheNANOG network can also be targeted to resensitize resistant cancer cells to conventional therapies. The current review focuses on NANOG regulation in the various signaling networks leading to cancer progression and chemoresistance, andhighlights the therapeutic aspect of targeting NANOG in various cancers.
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