Abstract
We report that Fe3O4@Au core-shell nanoparticles (NPs) serve as a multifunctional molecule delivery platform. This platform is also suitable for sensing the doxorubicin (DOX) through DNA hybridization, and the amount of carried DOX molecules was determined by size-dependent Fe3O4@Au NPs. The limits of detection (LODs) for DOX was found to be 1.839 nM. In our approach, an Au nano-shell coating was coupled with a specially designed DNA sequence using thiol bonding. By means of a high-frequency magnetic field (HFMF), a high release percentage of such a molecule could be efficiently achieved in a relatively short period of time. Furthermore, the thickness increase of the Au nano-shell affords Fe3O4@Au NPs with a larger surface area and a smaller temperature increment due to shielding effects from magnetic field. The change of magnetic property may enable the developed Fe3O4@Au-dsDNA/DOX NPs to be used as future nanocarrier material. More importantly, the core-shell NP structures were demonstrated to act as a controllable and efficient factor for molecule delivery.
Highlights
IntroductionThe past four decades have seen the foundations established for nanotechnologies to deliver therapeutic and diagnostic agents in one securer and more effective manner [1,2,3,4]
We reported the synthesis of Fe3 O4 @Au core-shell NPs, which serve as substrates for further application in multifunctional molecule delivery systems
DOX molecules can be controllably released from hyperthermia effect by means of high-frequency magnetic field (HFMF) triggering
Summary
The past four decades have seen the foundations established for nanotechnologies to deliver therapeutic and diagnostic agents in one securer and more effective manner [1,2,3,4]. With the development of nanotechnology, various nanoparticles (NPs), nanocarriers, or conjugates have been developed for various biomedical applications. Owing to their specific configurational properties and favorable physical–chemical characteristics [5,6], the goal of modulating both the pharmacokinetic and pharmacodynamic profiles of drugs can be achieved to enhance their therapeutic index [7,8,9]. Inorganic NPs have gradually become more popular in recent years.
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