Abstract
The tumor microenvironment (TME) plays a critical role in tumorigenesis and is composed of different cellular components, including immune cells and mesenchymal stromal cells (MSCs). In this review, we will discuss MSCs in the TME setting and more specifically their interactions with immune cells and how they can both inhibit (immunosurveillance) and favor (immunoediting) tumor growth. We will also discuss how MSCs are used as a therapeutic strategy in cancer. Due to their unique immunomodulatory properties, MSCs isolated from perinatal tissues are intensely explored as therapeutic interventions in various inflammatory-based disorders with promising results. However, their therapeutic applications in cancer remain for the most part controversial and, importantly, the interactions between administered perinatal MSC and immune cells in the TME remain to be clearly defined.
Highlights
It is clear that the tumor microenvironment (TME) is essential in tumorigenesis (Mantovani et al, 2008)
Different immune players are found in the TME, such as those pertaining to innate immunity [i.e., macrophages, neutrophils, mast cells, myeloid-derived suppressor cells (MSDCs), dendritic cells (DCs), and natural killer (NK) cells] and those of adaptive immunity (T and B lymphocytes) (Turley et al, 2015)
Immune cells within the TME give rise to an inflammatory response, which plays a fundamental role in all stages of tumor growth (Mantovani et al, 2008), where on one hand it can stimulate an anti-tumor immune reaction, and on the other hand it can be exploited to promote cancer progression (O’Donnell et al, 2019)
Summary
It is clear that the tumor microenvironment (TME) is essential in tumorigenesis (Mantovani et al, 2008). Immune cells within the TME give rise to an inflammatory response, which plays a fundamental role in all stages of tumor growth (Mantovani et al, 2008), where on one hand it can stimulate an anti-tumor immune reaction (immunosurveillance), and on the other hand it can be exploited to promote cancer progression (immunoediting) (O’Donnell et al, 2019).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
