Abstract
Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic material. Segregation of subcellular organelles during mitosis also needs to be tightly coordinated in order to warrant their proper inheritance and cellular homeostasis. The inheritance of mitochondria, a powerhouse of the cell, is tightly regulated in order to meet the high energy demand to fuel the mitotic machinery. Mitochondria are highly dynamic organelles, which undergo events of fission, fusion and transport during different cell cycle stages. Importantly, during mitosis several kinases phosphorylate the key mitochondrial factors and drive fragmentation of mitochondria to allow for their efficient distribution and inheritance to two daughter cells. Recent evidence suggests that mitochondrial fission can also actively contribute to the regulation of mitotic progression. This review aims at summarizing established and emerging concepts about the complex regulatory networks which couple crucial mitotic factors and events to mitochondrial dynamics and which could be implicated in human disease.
Highlights
Mitosis is a fundamental process in eukaryotes which ensures genome integrity by elegantly coordinating the segregation of duplicated chromosomes in order to give rise to genetically identical daughter cells (McIntosh, 2016)
Survivin is implicated in mitochondrial dynamics by facilitating the recruitment of Dynamin related protein 1 (DRP1) to mitochondria and promoting fission, a process correlated with repressed APC/CCDH1 expression, the exact mechanism is not yet known (Figure 2B; Hagenbuchner et al, 2013)
To our knowledge there are currently no studies addressing how fusion-related proteins are regulated in a cell cycledependent manner, with only one study showing that MFN1 is targeted for proteasomal-dependent degradation during G2/M transition by the mitochondrial E3 ubiquitin ligase MARCH5 (Park and Cho, 2012)
Summary
Reviewed by: Timothy Wai, Institut Pasteur, France Antonino Colanzi, National Research Council (CNR), Italy Kasturi Mitra, University of Alabama at Birmingham, United States. Specialty section: This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental
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