The Morphology of Cell Nuclei Regulates Calcium Coding in Hippocampal Neurons

Abstract

Event Abstract Back to Event The Morphology of Cell Nuclei Regulates Calcium Coding in Hippocampal Neurons Gillian Queisser1* 1 University of Heidelberg, Interdisziplinares Zentrum fur Wissenschaftliches Rechnen, Germany Calcium acts as a key regulator in the nucleus for biochemical events that trigger gene transcription and is involved in processes such as memory formation and information storage. Recent research shows that the morphology of hippocampal neuron nuclei is regulated by NMDA receptors, which led us to investigate the morphological influence in a modeling environment. We introduce novel concepts of neuron nuclei and their morphology as a regulator for nuclear calcium signaling. In a model study we developed a three-dimensional mathematical model for nuclear calcium signaling based on experimental data and three-dimensionally reconstructed cell nuclei. When investigating the influence of the nuclear morphology on calcium signals, we find two main types of nuclei, infolded and spherical. While spherical nuclei are observed to be "signal-integrators", infolded nuclei are adept at resolving high-frequency signals, an area not yet explored in detail until this point. Downstream of calcium, the morphology of nuclei might affect biochemical processes that are involved in gene transcription. Conference: Bernstein Conference on Computational Neuroscience, Frankfurt am Main, Germany, 30 Sep - 2 Oct, 2009. Presentation Type: Poster Presentation Topic: Information processing in neurons and networks Citation: Queisser G (2009). The Morphology of Cell Nuclei Regulates Calcium Coding in Hippocampal Neurons. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.neuro.10.2009.14.066 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Aug 2009; Published Online: 26 Aug 2009. * Correspondence: Gillian Queisser, University of Heidelberg, Interdisziplinares Zentrum fur Wissenschaftliches Rechnen, Heidelberg, Germany, gillian.queisser@bioquant.uni-heidelberg.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gillian Queisser Google Gillian Queisser Google Scholar Gillian Queisser PubMed Gillian Queisser Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.