Abstract
The Morphology and Growth Characteristics of a Transplantable Mammary Fibroadenoma in the Rat
Highlights
The tumour line which has been studied presented no unusual aspects with regard to morphology
The spontaneous tumour from which this line was initiated contained three distinct forms in the single section observed. These comprised areas of closely packed acini surrounded by strands of connective tissue (Fig. 4), areas of ducts dispersed in a connective tissue stroma (Fig. 5) and an area of connective tissue alone
Epithelial or connective tissue development and the incidence of fibrosarcomata varied randomly in the course of twelve generations of transplantation, the tumour line maintaining its identification of benign fibroadenoma
Summary
Young adult Sprague Dawley rats were used in the experiments to be described. For each transplant series the rats were of the same age. When the experiment was completed the tumnour areas were plotted against time (in days) and growth curves drawn From these graphs, the times for the tumour to grow from the time of implantation to an area of 0-4 square inches and from 0.4 to 3.0 square inches were determined. If the tumour conltained areas of atypical tissue, portions of these areas were kept for sectioning For confirmation of the histological report this tissue was usually transplanted into four or five rats and the growth characteristics and morphology of the transplanted growths observed It has been the aim of this research to study one tumour line in its course through a series of progressive transplantations and under various experimental conditions.
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