Abstract
1. Degranulation of B-cells of rats infused with guinea-pig anti-insulin serum (AIS) for 3-4 hrs can be prevented completely by previous injection of diazoxide. Tolbutamide added to the AIS infusion abolishes the diazoxide effect on granule release.2. Rats fed with 500 mg/kg diazoxide twice daily for 1-4 days show ultrastructural changes in the B-cells (multigranular sacs and granule-containing dense bodies). This suggests intracellular digestion of beta granules when granule release is blocked. Rats fed for 2 weeks with 500 mg/kg diazoxide twice daily show degranulated B-cells similar to those seen in long-term insulin treatment. Signs of intracellular digestion are still visible.
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