Abstract
AbstractThe in vivo effects of parathyroid extract (PTE) on the formation of the embryonic chick humerus and femur were examined. PTE had a considerable effect on mortality (increased) and ossification (inhibited). Group I embryos were injected with 0.1 ml PTE on day 4 of incubation; their survival rate was 71% which encompassed the experimental period through day 15. Group II embryos were injected with 0.1 ml PTE on day 6; only 32% survived through day 7 and none were alive after day 9. Until the effects of PTE were overcome as seen in Group I nine‐day embryos, PTE (1) inhibited ossification, (2) retarded development of the cartilage model and (3) caused chondrolysis of the capsular matrix in the zone of cellular hyperthrophy. PTE did not appear to cause (1) increased formation of osteoclasts, (2) formation of fibrous connective tissue instead of osteoid or (3) reversion of bone cells to a more primitive or multipotential bone type. It is suggested that the toxic effect of PTE on Group II embryos relates to its application at a critical stage of development.
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