Abstract
Disorders of the central nervous system observed in patients with chronic HCV infection seem to be associated with excitotoxic lesion of neurons caused by infected microglial cells. Despite the high interest in this problem, the morphological changes of infected microglia remain uninvestigated. The paper presents the results of the morphologic study of microglial reactions in white matter of the brain in 40 patients who died of chronic HCV-infection. The study found the structural and quantitative changes of infected microglia in different parts of the brain, which is caused by the activation of these cells by HCV.
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