Abstract
BackgroundFDG-PET/CT is part of the standard diagnostic management of a patients with a large variety of common and less common malignant tumors, based on the increased glucose metabolism within tumors.Case presentationA hybrid fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) was performed in a neurofibromatosis patient to rule out relapse of malignant peripheral nerve sheet tumor. The scan revealed non-malignant neurofibromas, a testis seminoma and hypermetabolic syphilitic granulomata.ConclusionThis case stresses the need to rule out infectious diseases when atypical hypermetabolic lesions are present.
Highlights
FDG-PET/CT is part of the standard diagnostic management of a patients with a large variety of common and less common malignant tumors, based on the increased glucose metabolism within tumors. It is useful for detecting malignant transformation of neurofibromas to MPNST, as malignant MPNST is characterized by higher FDG uptake
Case presentation A 32 year-old homosexual Caucasian male with neurofibromatosis type I (NF1), café-au-lait patches and known superficial and deep neurofibromas consulted us for unexplained fatigue and weight loss
Adjuvant radiotherapy or systemic chemotherapy as options for stage I seminoma, and the patient opted for adjuvant carboplatin AUC 7
Summary
Background FDG-PET/CT is part of the standard diagnostic management of a patients with a large variety of common and less common malignant tumors, based on the increased glucose metabolism within tumors. Interpretation of FDG-PET images should be done with full knowledge of the case record of the patient. FDG-PET/CT was performed to exclude the presence of a NF1-related malignancy (e.g., malignant peripheral nerve sheet tumor, MPNST).
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