Abstract
Publisher Summary This chapter discusses the monoamine innervations of rat cerebral cortex. Substantial evidence recently obtained from experiments carried out on the monoaminergic systems of the mammalian brain indicates that molecular communication between nerve cells may take various forms differing from the traditional views on synaptic transmission. Another new concept evolved from the notion that in certain parts of the central nervous system, a high proportion of monoamine axon terminals lacks the membranous apposition and specializations that characterize synapses in electron micrographs. This finding led to the suggestion that the biogenic amines released from such nonsynaptic nerve endings might reach remote receptors: A mode of operation intermediate between the private addressing of classical synaptic messengers and the broadcasting of neuroendocrine secretion. The chapter presents the main body of radioautographic data that gave rise to this hypothesis and discusses some of their cytological and functional implications.
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