Abstract
SummaryBackgroundObesity is one of the most common modern health problems worldwide. Proinflammatory cells accumulate in the adipose tissue of the obese, and the presence of a low level chronic inflammation in obesity is associated with the emergence of a range of metabolic disorders in cluding cardiovascular disease, insulin resistance, type-2 diabetes, fatty-liver disease, and others. Neutrophils are early parti - cipants in inflammatory processes. After the appropriate stimu lation, these cells release reactive oxygen and nitrogen species, which leads to degranulation and secretion of myeloperoxidase and other enzymes. Myelo per oxidase and its reactive oxidants contribute to tissue damage during inflammatory processes in the human body.MethodsThe study included 175 subjects who were, in com - pliance with the International Diabetes Federation criteria, divided into 3 groups: normal weight subjects (N=106), subjects with abdominal obesity (N=37) and the third group consisted of subjects with the metabolic syndrome (N=32).ResultsBy analyzing the myeloperoxidase enzyme activity (kU/L), and the levels of high-sensitivity C-reactive protein in the blood of all subjects, we detected their significantly higher activity and levels in subjects with the metabolic syndrome, as compared to normal weight subjects (p<0.001).ConclusionsBased on our results, we can conclude that the MPO activity in the serum progressively increases with obesity and the metabolic syndrome, which indicates that this prooxidant enzyme may play a role in the pathophysiological mechanisms of the obesity and the metabolic syndrome related complications.
Highlights
Obesity is a complex metabolic disorder, and one of the most common modern health problems
Proinflammatory cells accumulate in the adipose tissue of the obese, and the presence of a low level chronic inflammation in obesity is associated with the emergence of a range of metabolic disorders including cardiovascular disease, insulin resistance, type-2 diabetes, fatty-liver disease, and others
For this group of subjects, the measured level of triacylglycerol was up to 1.70 mmol/L, HDL cholesterol above 1.03 mmol/L in men, and above 1.29 mmol/L in women, blood glucose was below 5.6 mmol/L, systolic blood pressure was lower than 130 mmHg and diastolic lower than 85 mmHg
Summary
Obesity is a complex metabolic disorder, and one of the most common modern health problems. The presence of a large number of macrophages in the adipose tissue of obese is probably caused by the reaction of adipose tissue to stress signals released by adipocytes [5], but the molecular events that initiate the recruitment and activation of immune system cells in adipose tissue of the obese are not yet fully known. Multiple inflammatory stimuli such as the increase in circulating cytokines, the reduction of protective factors (e.g. adiponectin) and the communication between inflammatory and metabolic cells, contribute to the onset of metabolic disorders in the body of the obese people. Myeloperoxidase that is present in neutrophils may be involved in the initiation of an inflammatory response in the adipose tissue of the obese
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