Abstract
Mitochondria play a role as intracellular calcium stores as well as energy conversion functions. Mitochondrial calcium uptake is mediated by mitochondrial calcium ion channel, “calcium uniporter”. In this decade, the molecular composition of the calcium uniporter complex was discovered; the calcium uniporter consists of the 7 subunits. Using the yeast reconstitution technique, we showed that MCU and EMRE are core subunits of the complex. The yeast reconstitution technique has also enabled us to perform detailed structure-function analysis of the MCU and EMRE. In this review, we will discuss the molecular mechanism of mitochondrial Ca2+ uptake.
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