Abstract
Glioblastomas (GBM) are among the most malignant and frequent human tumors, characterized by rapid growth, metastasis, resistance to therapy and formation of relapses. The appearance of multidrug resistances (MDR) in GBM cells are often combined with inhibition of cell death and differentiation pathways and prevents an increase in the effectiveness of therapy in this group of patients. The review examines the relationship of molecular mechanisms of MDR with differentiation and apoptosis of GBM with an emphasis on identifying new targets among proteins, microRNAs, suppressor genes, and oncogenes.
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