Abstract
Biological fluids from several sources (e.g. blood, fertal urine, amniotic fluid) have been shown to contain factors that modulate prostaglandin (PG) synthesis. In this study, we investigated the possibility that peritoneal fluid contains substances that may regulate PG synthesis. Peritoneal fluids were obtained from women undergoing diagnostic laparoscopy for infertility. Fluids from women without evident pelvic pathology were incubated with prostaglansin synthase prepared from bull seminal vesicles in the presence of excess arachidonic acid, and the production of PGE 2, PGF 2α, and 6-keto-PGF 1α was quantified by specific radioimmunoassay. The untreated fluids potently the synthesis of PGE 2 but such inhibitory activity was not extractable by chloroform:methanol. An ultrafiltrate of the fluid containing molecular smaller than 10,000 Daltons stimulated PGF 2α synthesis but this activity was also lost after extraction. The extracted fluid did, however, stimulate the synthesis of prostacyclin (as reflected by 6-keto-PGF 1α).
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