Abstract
BackgroundTo prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studies have shown that non-invasive brain stimulation (NIBS) is beneficial to improve cognitive function of MCI patients. However, whether NIBS is conducive to the protection of cognitive ability in MCI patients remains unknown due to limited evidence. The aim of the study was to systematically evaluate the modulation effect of NIBS on cognitive function (global cognitive ability and specific domains of cognition) in patients with MCI.ResultsA total of 11 RCTs comprising a total of 367 MCI participants. Meta-analysis showed that NIBS can significantly improve global cognition (n = 271, SMD = 0.94, 95% CI 0.47–1.41, p < 0.0001) and verbal fluency (n = 72, MD = 2.03, 95% CI 0.17–3.88, p = 0.03). However, there was no significant improvement in other domains of cognition.ConclusionsNIBS has a positive effect on improving global cognitive function and verbal fluency. At the same time, it has a small positive effect on improving executive function. However, these findings should be interpreted carefully due to the limitations of the study.
Highlights
To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia [4]
There has been an increased interesting on the use of non-drug therapy to improve the cognitive function of MCI patients [9]
Study identification According to the original search strategy, 510 studies were retrieved, and 72 repetitive studies were excluded
Summary
To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studies have shown that non-invasive brain stimulation (NIBS) is beneficial to improve cognitive function of MCI patients. Studies have shown that as a new type of treatment, non-invasive brain stimulation (NIBS) is beneficial to improve cognitive function of MCI. Unlike TMS, tDCS delivers a continuous week currents (0.5–2.0 mA) to the scalp to modulate neuronal transmembrane potential toward hyperpolarization or depolarization, thereby altering plasticity in the stimulated brain regions [10, 14]. They are different in some respects, both tools can induce long-term after effects on cortical excitability and neuroplasticity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
