Abstract
The Chikungunya virus (CHIKV) is an alphavirus transmitted to people by Aedes mosquitoes, usually Aedes aegypti and Aedes albopictus. The virus causes Chikungunya fever, a disease characterized by fever, nausea, headaches, rash, and persistent arthralgia. Chikungunya fever may be associated with severe complications, including death. Since 2005, CHIKV has spread worldwide, leading to epidemics in Africa, Indian Ocean islands, Asia, and, most recently, in the Americas. Globally expanding pandemics with CHIKV rheumatic disorders and post-infectious complications are exacerbating public health problems. There is no specific vaccine or drug to treat this viral infection. Analysis of the search for effective drugs in relation to CHIKV showed that, despite the diversity of research areas, as well as the use of modern advances in molecular biology, there are no etiotropic treatments or medicinal immunobiological preparations (MIBPs) approved for use in practical medicine. However, new strategies for antiviral research are encouraging (inspire optimism?). Combined chemotherapy with interferons and antiviral agents is an appealing therapeutic strategy for providing increased antiviral activity and reducing drug concentrations.
Highlights
Âèðóñ ×èêóíãóíüÿ (CHIKV) — ýòî àëüôà-âèðóñ, ïåðåäàâàåìûé ëþäÿì êîìàðàìè Aedes, òðàäèöèîííî Aedes aegypti è Aedes albopictus
The Ñhikungunya virus (CHIKV) is an alphavirus transmitted to people by Aedes mosquitoes, usually Aedes aegypti and Aedes albopictus
Ñóðàìèí®, òàêæå èçâåñòíûé êàê Germanin èëè Bayer-205, ÿâëÿåòñÿ çàðåãèñòðèðîâàííûì íà ðûíêå ëåêàðñòâîì, îäíàêî ïðîÿâëÿåò çíà÷èòåëüíûå ïîáî÷íûå ýôôåêòû, ÷òî, âåðîÿòíî, ïðåïÿòñòâóåò åãî èñïîëüçîâàíèþ â êà÷åñòâå ïðåïàðàòà äëÿ ëå÷åíèÿ CHIKV, íî èç-çà âûñîêîé ëåòàëüíîñòè âèðóñíûõ èíôåêöèé, âûçâàííûõ âèðóñîì Ýáîëà, Ñóðàìèí® ìîæåò áûòü èñïîëüçîâàí ïðîòèâ èíôåêöèè Ýáîëà [16]
Summary
Âèðóñ ×èêóíãóíüÿ (CHIKV) — ýòî àëüôà-âèðóñ, ïåðåäàâàåìûé ëþäÿì êîìàðàìè Aedes, òðàäèöèîííî Aedes aegypti è Aedes albopictus. Áûëî îáíàðóæåíî, ÷òî íèêëîçàìèä è íèòàçîêñàíèä: 1) îãðàíè÷èâàþò ïðîíèêíîâåíèå âèðóñà; 2) èíãèáèðóþò êàê âûñâîáîæäåíèå âèðóñà, òàê è ïåðåäà÷ó îò êëåòêè â êëåòêó; 3) îáëàäàþò øèðîêîé àíòè-àëüôàâèàëüíîé àêòèâíîñòüþ, â òîì ÷èñëå ïðîòèâ äâóõ êëèíè÷åñêèõ èçîëÿòîâ CHIKV è äâóõ àëüôà-âèðóñîâ: âèðóñ Ñèíäáèñ (SINV) è âèðóñ ëåñà Ñåìëèêè (SFV). Ïîëó÷åííûå äàííûå, ïî-âèäèìîìó, óêàçûâàþò íà òî, ÷òî àêòèâíîñòü àíòè-CHIKV ìîæåò áûòü ñâÿçàíà ñ èíãèáèðîâàíèåì ýòîé âàæíîé ñòàäèè — êýïèðîâàíèåì âèðóñíîé ÐÍÊ [5].
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