Abstract
Little is known about the shift of lymphocytes under the condition of the model for end-stage liver disease score and the follow-up period. Then, we detected the peripheral blood from liver transplant recipients by flow cytometry and compared the results. The model for end-stage liver disease score affected the percentages of T-cell subsets and B cells during the short-term follow-up period, but failed to influence the lymphocyte subsets during the long-term follow-up period. In contrast, the follow-up period not only affected the absolute counts of T-cell subsets and natural killer (NK) cells in patients with the low model for end-stage liver disease scores, but also influenced the percentages and absolute counts of T-cell subsets in patients with the high model for end-stage liver disease scores. In the two-way ANOVA, we further revealed that the model for end-stage liver disease score was associated with the percentages of T cells and CD4+ T cells and the absolute numbers of T-cell subsets and B cells, while the follow-up period was associated with the percentages of T-cell subsets and the absolute numbers of lymphocyte subsets. Therefore, patients with either the low model for end-stage liver disease scores or the long-term follow-up period are in a relatively activated immune condition.
Highlights
Liver transplantation is a promising procedure for patients with benign and malignant liver diseases
liver transplant recipients (LTR) was divided into four groups depending on the model for end-stage liver disease (MELD) score and the followup period including the LmLf group, the high MELD score and long-term follow-up (HmLf) group, the low MELD score and short-term follow-up (LmSf) group, and the HmSf group
The absolute counts (Figure 3 and Table 3) of T-cell subsets and natural killer (NK) cells rather than B cells were significantly different between the groups (p < 0.05). These results showed that T-cell subsets and NK cells from patients with mild liver disease proliferated significantly over the follow-up period
Summary
Liver transplantation is a promising procedure for patients with benign and malignant liver diseases. These patients are universally plagued by immunosuppression-related complications following liver transplantation, especially acute rejection during the posttransplant period [1,2,3]. The model for end-stage liver disease (MELD) score has been widely accepted as a fair and objective method for liver transplant allocation, which is based on disease severity [4]. The correlation between the preoperative MELD score and the occurrence of acute rejection is uncertain. Jia et al [5] found that liver transplant recipients (LTR) with rejection had higher MELD scores. Similar results were described in adult-to-adult living donor liver transplantation [6]. Selzner et al [7] reported that there were no differences between
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