The mode of coupling of adenylate cyclase to hormone receptors and its modulation by GTP

Abstract

1. The motor and interneurones in the identified neural network regulating the cardio-renal system of Helix pomatia L, produced differing effects with ACh, 5HT, DA and OP. They were less sensitive to glutamate.2. On the double action interneuron the sensitivity to the neurotransmitters was modified by the source of input and the sequence of their application.3. The interneuron V21 uses ACh and 5HT as neurotransmitters. Seven afferent excitatory pathways terminate on interneuron V21.4. The efferent pathways of interneuron V21 can be selectively blocked by haloperidol and ergotamine.5. The peptide-like factor released spontaneously following haloperidol and ergotamine treatment block the cholinergic and aminergic pathways onto interneuron V21, while the amino acid mechanism remains unaltered.