The Modality Effect on Delayed Free Recall in Non-demented Patients With Mild Parkinson's Disease Progression.

Constantinos Kormas,Constantin Potagas,Elisabeth Kapaki,Ioannis Zalonis,Ioannis Evdokimidis

doi:10.3389/fnagi.2019.00189

Abstract

Background: The modality effect plays the central role in learning and memory functions. Retrieval failure constitutes a common memory impairment that occurs among patients with Parkinson’s disease (PD). However, little knowledge exists about the relation between modality effect and delayed recall impairment in PD. The primary goal of this study was to compare delayed free recall performance between three different memory modalities (verbal, visual, and cross visual-verbal) in a sample of non-demented patients with mild PD progression. The secondary goal was to explore the frequency of deficient performance on the basis of normative comparisons on each of the three delayed free-recall measures.Method: A total of 71 non-demented patients with mild PD progression were recruited for the administration of the Montreal Cognitive Assessment (MoCA), the Rey Auditory Verbal Learning Test (RAVLT), the Rey Osterrieth Complex Figure Test (ROCFT), and the Greek Version of Face-Name Associative Memory Examination (GR-FNAME12).Results: The percentages of deficient-performances for the three delayed free recall measures were 45.1% (32/71), 39.4% (28/71) and 31% (22/71) for the GR-FNAME12, ROFCT and RAVLT, respectively. The results indicated no significant difference between performances of the GR-FNAME12 and ROCFT, both of which were significantly lower than performance on the RAVLT.Conclusions: In conclusion, delayed free recall appears to be more severely affected in the cross visual-verbal and visual memory modalities than in verbal-memory modalities in the early phase of PD progression.

Highlights

Parkinson’s disease (PD) is a neurodegenerative disease manifested by dopaminergic loss in the substantia nigra and characterized by frontal-striatal dysfunction (Davie, 2008)
These findings have formed the basis of a hypothesis that PD memory dysfunction is due to a failure in retrieval mechanisms associated with fronto-striatal pathology, which appears to reflect an executive deficit with secondary negative effect to the primary memory system (Tröster and Fields, 1995)
No significant difference was observed between performances of the GR-FNAME12 and Rey Osterrieth Complex Figure Test (ROCFT) (Table 1)

Summary

Introduction

Parkinson’s disease (PD) is a neurodegenerative disease manifested by dopaminergic loss in the substantia nigra and characterized by frontal-striatal dysfunction (Davie, 2008). Some research studies propose that patients with PD perform worse in delayed free recall tasks and better in recognition tasks (Higginson et al, 2005) These findings have formed the basis of a hypothesis that PD memory dysfunction is due to a failure in retrieval mechanisms associated with fronto-striatal pathology, which appears to reflect an executive deficit with secondary negative effect to the primary memory system (Tröster and Fields, 1995). In this context, patients with PD maintain the ability to access stored memories (recognition), while exhibiting difficulty or failure to initiate, organize and maintain efficient retrieval strategies (free recall). The secondary goal was to explore the frequency of deficient performance on the basis of normative comparisons on each of the three delayed free-recall measures

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