The Mn‐zeolite/Graphite Modified Glassy Carbon Electrode: Fabrication, Characterization and Analytical Applications

Abstract

AbstractIn this work, low‐cost and environmentally friendly natural zeolite exchanged with Mn2+ cations was used for the first time to modify the glassy carbon electrode with the aim to obtain a fast and simple sensor for voltammetric determination of paracetamol (PAR). The Mn‐zeolite/graphite modified glassy carbon electrode (MnZG−GCE) was prepared by evaporation of solvent from dispersion of the zeolite/graphite mixture with the polymer in acetone. The electrochemical characteristics of MnZG−GCE were conducted by electrochemical impedance spectroscopy and cyclic voltammetry. Compared with graphite modified GCE (G−GCE), MnZG−GCE exhibited better electrochemical parameters, which confirms the superiority of applying zeolite in the proposed sensor. The optimization of the pH‐value of supporting electrolyte and instrumental parameters were carried out. The peak current was proportional to the concentration of PAR in a phosphate buffer saline of pH 6.0 in the range from 0.029 to 0.69 mg L−1 (R=0.9997) with limit of detection of 8.8 μg L−1. Finally, the proposed electrode was successfully applied to determine the paracetamol in pharmaceutical formulation and certified reference materials. The satisfactory recoveries, which ranged from 89.2 to 102.7 %, were obtained for all studied samples. It confirmed the attractiveness of relatively inexpensive, easy to fabricate and non‐toxic MnZG−GCE in determination of PAR in complicated matrixes.