Abstract
SUMMARY Skin graft survival time, serological detection of Ag-B antigens, and mixed leucocyte reaction have been studied using F2 generation rats as recipients and parental or F1 strain rats as donors. The results indicate a good correlation between these three tests and no evidence of “false negative MLR's” was found. Three F2 rats showed some discrepancy between MLR and survival time of the grafts. It is suggested (1) that this may be the result of the occurrence of crossing over in the region of the chromosome where the subloci of the Ag-B antigenic complex is situated, and (2) therefore, that, in the rat, as in man, not all antigenic specificities of the strong H-antigenic complex are of importance in determining the outcome of the MLR.
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