Abstract
Summary The effect of heparin on the mitotic count in the epithelium of the gastrointestinal canal and the parenchyma of regenerating liver was studied in intact and hepatectomized rats. Heparinization caused a significant reduction in the mitotic counts of the gastric mucosa and regenerating liver. Heparinization and hepatectomy caused no changes in the number of mitoses in the mucosal epithelium of the duodenum, ileum, and colon. The mitotic inhibition in the gastric mucosa and in the cells of the parenchyma of regenerating liver was assumed to be due to the inhibitory effect of heparin on the nucleic acid synthesis which does not influence intestinal mucosa.
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