Abstract
Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator in physical capacity and performance. Exercise elevates levels of endogenous MOTS-c in circulation and in myocardium, while MOTS-c can significantly enhance exercise capacity. However, the effects of aerobic exercise combined with MOTS-c on cardiac structure and function are unclear. We used pressure–volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c. Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function. The findings suggest that using exercise supplements could be used to modulate the cardiovascular benefits of athletic training.
Highlights
Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes
We examined the effects of MOTS-c on cardiac function and structure (using hematoxylin–eosin (HE) staining, transmission electron microscopy, and echocardiography) in rats exposed to chronic aerobic exercise
Our findings provide an experimental basis for the use of putative exercise supplements to modulate the cardiovascular benefits of athletic training
Summary
Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial-derived peptide MOTS-c (mitochondrial open-reading frame of the twelve SrRNA type-c) is a peptide recently discovered by Lee et al, containing 16 amino acid, and it is expressed mainly in the blood plasma, skeletal muscle and heart, both in rodents and human being[11,12] This peptide performs various function, as an important cyto-protector in helping to maintain the mitochondrial function and the cellular viability under stressful conditions, (such as exercise), which has led several g roups[13,14,15] to propose that MOTS-c could mimic the benefits of exercise training. Our findings provide an experimental basis for the use of putative exercise supplements to modulate the cardiovascular benefits of athletic training
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