Abstract
Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on snails and worms, respectively. Here, we report the mitochondrial genome sequence of the fish-hunting cone snail Conus consors and describe a novel putative control region (CR) which seems to be absent in the mitochondrial DNA (mtDNA) of other cone snail species. This possible CR spans about 700 base pairs (bp) and is located between the genes encoding the transfer RNA for phenylalanine (tRNA-Phe, trnF) and cytochrome c oxidase subunit III (cox3). The novel putative CR contains several sequence motifs that suggest a role in mitochondrial replication and transcription.
Highlights
Most metazoan mitochondrial genomes contain 37 genes for 13 protein subunits of the oxidative phosphorylation enzymes, two ribosomal RNAs and 22 transfer RNAs [1]
The heavy strand of the mitochondrial DNA (mtDNA) molecule consisted of 27.7% adenine (A), 13.5% cytosine (C), 19.4% guanine (G) and 39.4% thymine (T) with a total (A/T) content of 67.1%
All protein coding genes as well as the transfer RNAs (tRNAs) for Asp, Val, Leu1-2, Pro, Ser1-2, His, Phe, Lys, Ile, Ala, Arg, Asn and both ribosomal RNA genes were located on the heavy strand of the mtDNA molecule
Summary
Most metazoan mitochondrial genomes contain 37 genes for 13 protein subunits of the oxidative phosphorylation enzymes, two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs) [1]. 13 entire mitochondrial genomes have been reported so far [5,6,7,8,9]. These genomes share a highly conserved gene arrangement with only two cases of tRNA gene translocations [7]. Animal mitochondrial genomes are organized very tightly. They exhibit short intergenic sequences and neighboring genes may even overlap. The origin of replication and transcriptional start sites have been identified in this region, leading to the designation of this mtDNA section as the control region (CR) [10]
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