Abstract
Cold-stored platelets are making a comeback. They were abandoned in the late 1960s in favor of room-temperature stored platelets due to the need for longer post-transfusion platelet recoverability and survivability in patients with chronic thrombocytopenia. However, the current needs for platelet transfusions are rapidly changing. Today, more platelets are given to patients who are actively bleeding, such as ones receiving cardiac surgeries. It has been established that cold-stored platelets are more hemostatically effective, have reduced bacterial growth, and have longer potential shelf lives. These compelling characteristics led to the recent interest in bringing back cold-stored platelets to the blood systems. However, before reinstating cold-stored platelets in the clinics again, a thorough investigation of in vitro storage characteristics and in vivo transfusion effects is required. This review aims to provide an update on the recent research efforts into the storage characteristics and functions of cold-stored platelets using modern investigative tools. We will also discuss efforts made to improve cold-stored platelets to be a better and safer product. Finally, we will finish off with discussing the relevance of in vitro data to in vivo transfusion results and provide insights and directions for future investigations of cold-stored platelets.
Highlights
Cold-stored platelets (CPs) are not a new product
It was discovered that cold storage induces the clustering of platelet surface glycoprotein GPIbα, which has been shown to mediate phagocytosis by macrophages in short-term (
Since the majority of platelet transfusions were given to patients with hematological disorders or thrombocytopenic patients in the late 1970s, there was a complete shift in platelet storage methodology from CPs to room-temperature stored platelets (RPs)
Summary
Cold-stored platelets (CPs) are not a new product. Prior to the late 1970s, all platelet units used for transfusions were stored at 4 ◦ C. Storage in cold temperature has significant effects on the metabolism of stored the cold has been associated with preservation of the mitochondrial functions of the platelets. The cold has been associated with preservation of the mitochondrial functions of the Despite the rapid in vivo clearance, there has been a renewed interest in bringing back platelets [11] This recent can be to three main in reasons. The rapid in vivoresurgence clearance, there hasattributed been a renewed interest bringingFirst, cold storage significantly reduces the growth of microorganisms, such as bacteria, in the back CPs as a product. This recent resurgence can be attributed to three main reasons. The box shaded with red and green colors represents conflicting effects of cold storage on platelet surface receptors
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