The migration activity of leukocytes as indicator of hyper-sensitivity of delayed type in patients with erysipelas.

Abstract

The hyper-sensitivity of delayed type is one of important manifestations of cellular immunity. The successful studying of this phenomenon can favor solution of actual issues of pathogenesis, diagnostics and treatment of bacterial infections. The present review considers hyper-sensitivity of delayed type as an important area of cellular immunity under infectious pathology and macrophage-inhibiting factor as an important lymphocyte mediator: cytokine and hormone. The model of intestinal infections and erysipelas was used to demonstrate an important diagnostic and prognostic value of screening test of cellular migration as a simple, handy in application and reading of results, relatively new technique permitting to evaluate both acceleration of migration of leukocytes at height of disease and inhibition of migration in re-convalescence of disease. The establishment of character and dynamics of migration activity of leukocytes on partial genes antigens S.pyogenes in screening test of cellular migration can be used in diagnostics of various forms of erysipelas, evaluation of expression of intoxication, prognosis of complications and relapses. The disturbance of dynamics of migration activity of leukocytes testifies failure of immune response to agent.