Abstract
A quantitative ultrastructural study of microtubules in Purkinje cell dendrites of normal and hypothyroid developing rats was performed after fixation either at room or at low temperature (4°C). In normal animals, the density of microtubules and their fold-stability increased with age, more especially during the period of intense dendritic growth. Thyroid deficiency delayed the appearance of microtubules and still more the acquisition of their fold-stability. These effects might explain the defects in Purkinje cell dendritic growth and branching observed in hypothyroid animals.
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