Abstract
BackgroundsSurgical resection and adjunct chemotherapy or radio-therapy has been applied for the therapy of superficial malignant tumor in clinics. Whereas, there are still some problems limit its clinical use, such as severe pains and side effect. Thus, it is urgent need to develop effective, minimally invasive and low toxicity therapy stagey for superficial malignant tumor. Topical drug administration such as microneedle patches shows the advantages of reduced systemic toxicity and nimble application and, as a result, a great potential to treat superficial tumors.MethodsIn this study, microneedle (MN) patches were fabricated to deliver photosensitizer IR820 and chemotherapy agent cisplatin (CDDP) for synergistic chemo-photodynamic therapy against breast cancer.ResultsThe MN could be completely inserted into the skin and the compounds carrying tips could be embedded within the target issue for locoregional cancer treatment. The photodynamic therapeutic effects can be precisely controlled and switched on and off on demand simply by adjusting laser. The used base material vinylpyrrolidone—vinyl acetate copolymer (PVPVA) is soluble in both ethanol and water, facilitating the load of both water-soluble and water-insoluble drugs.ConclusionsThus, the developed MN patch offers an effective, user-friendly, controllable and low-toxicity option for patients requiring long-term and repeated cancer treatments.
Highlights
Superficial malignant tumor, including squamous cell carcinoma, malignant melanoma and breast cancer, is the most common tumors worldwide that with increasing morbidity and mortality [1]
The MN could be completely inserted into the skin and the compounds carrying tips could be embedded within the target issue for locoregional cancer treatment
Surgical resection and adjunct chemotherapy or radio-therapy has been applied for the therapy of superficial malignant tumor in clinics
Summary
Superficial malignant tumor, including squamous cell carcinoma, malignant melanoma and breast cancer, is the most common tumors worldwide that with increasing morbidity and mortality [1]. Surgical resection and adjunct chemotherapy or radio-therapy has been applied for the therapy of superficial malignant tumor in clinics. There are still some problems limit its clinic application. Surgery is quite invasive that requires long time to recover and remains high risks once the tumor tissues are removed incompletely. Patients with other diseases, such as heart failure, could not tolerate. Fu et al J Nanobiotechnol (2020) 18:146 surgery. Drug resistance result in unsatisfied efficacy of many chemotherapy drugs in the therapy of superficial malignant tumor, indicating by poor response duration and survival of patients [2, 3]. It is urgently needed to explore effective and low toxicity therapy stagey for superficial malignant tumor
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