Abstract
The BioLector® Pro system from m2p‐labs GmbH uses microtiter plates (MTPs) with an integrated microfluidic chip. By using microfluidic technology, the system can successfully carry out small‐scale fed‐batch cultivations. Working volumes of 0.8–1.5 mL are used to conduct cultivations as they were only as yet possible in lab fermenters. The measurements of biomass, fluorescence, pH and dissolved oxygen are performed by non‐invasive optical methods. The control of pH and feeding rates are realized by micro‐valves and micro‐channels. For the first time, these unique microfluidic components achieve continuous feeding and pH control on an MTP format. Altogether, 32 bioreactor wells and 16 reservoir wells are placed on one plate. That means 32 fed‐batch cultivations can be run in parallel, completely automated, with extensive data output.
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