Abstract
The biotransformation of 7α-hydroxy- ent-kaur-16-ene ( epi-candol A) by the fungus Gibberella fujikuroi gave 7α,16α,17-trihydroxy- ent-kaur-16-ene and a seco-ring B derivative, fujenoic acid, whilst the incubation of candicandiol (7α,18-dihydroxy- ent-kaur-16-ene) and canditriol (7α,15α,18-trihydroxy- ent-kaur-16-ene) afforded 7α,18,19-trihydroxy- ent-kaur-16-ene and 7α,11β,15α,18-tetrahydroxy- ent-kaur-16-ene, respectively. The presence of a 7α-hydroxyl group in epi-candol A avoids its biotransformation along the biosynthetic pathway of gibberellins, and directs it to the seco-ring B acids route. The 15α-hydroxyl group in canditriol inhibits oxidation at C-19 and direct hydroxylation at C-11(β). The formation of fujenoic acid, from 7α-hydroxy- ent-kaur-16-ene, probably occurs via 7α-hydroxykaurenoic acid and 7-oxokaurenoic acid, with subsequent hydroxylation at the C-6(β) position.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
