Abstract

1. The thread-like bodies isolated from human leucocyte nuclei and carp erythrocyte nuclei have been studied by means of the electron microscope and with the aid of microchemical stainings: 2. The thread-like bodies are composed of two parts of different density, that is, the proximal chromatin granule opaque in the electron beam, and the distal less opaque thread. 3. The light microscope analysis makes it certain that only chromatin granules are stained with Feulgen's reagent and methyl green, while chromatin threads are composed of basic proteins. 4. The chromatin thread is composed of a pair of small coiled chromonemata which are united into a double-stranded or pseudosingle-stranded spiral which frequently gives the image of a triple helix. 5. The chromonema consists of at least four chromofibrils of approximately 5–10 mμ in diameter. 6. The image, taken out of focus, of the orthospiral of two small coiled wires looks like a lampbrush chromosome.

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