Abstract
Abstract The Michael addition of diethyl malonate to ethyl crotonate-(carbonyl-C14) was carried out with one equivalent of sodium ethoxide. The addition product, diethyl α-ethoxycarbonyl-β-methylglutarate, was hydrolyzed to the corresponding acid. It was decarboxylated by heating to give β-methylglutaric acid, which was found to contain most of the radioactivity originally present in the ethyl crotonate. Thus, it was demonstrated that the migration of an ethoxycarbonyl group did not take place in contrast to the case with diethyl methylmalonate. The mechanism is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
